Åkerman played Kate Harrison, the third wife of Pete Harrison (Bradley Whitford).
Marcia Gay Harden and Michaela Watkins also star as Pete's ex-wives.
In the early 2000s, she had many television and film parts, including The Utopian Society (2003) and Harold & Kumar Go to White Castle (2004).
Following a supporting role on the comedy series The Comeback (2005), Åkerman gained her first starring roles in the feature films The Heartbreak Kid (2007) and 27 Dresses (2008).
Matt Webb Mitovich of TVLine said she "no less than shines here, coming off as fun-loving but not flaky, warm and not overheated".
She got married to her long-time boyfriend, Italian musician, Roberto Zincone on June 20, 2007, whom she met in 2003 as the band members of the band "The Petalstones".
She became known for making appearances in several Canadian productions.
In an interview for Daily Mail, she commented, "I spent a lot of time as a child in Sweden; it’s natural there ...
I don't know many women who go to bed with their husband at night and have sex with a bra on ...